School of Medicine - Clinical MedicineRespiratory Medicine




The Respiratory Medicine department, which was the first of its kind to be established in the Hokuriku region, has 37 hospital beds, including 7 beds in the respiratory care unit (RCU) in Kanazawa Medical University Hospital. We provide quick response to patients with respiratory diseases, such as pneumonia, chronic obstructive pulmonary disease (COPD), and bronchial asthma. Our department also plays a central role in the diagnosis and treatment of sleep apnea syndrome and interstitial pneumonia. In our research, we are putting special attention on the pathophysiology of COPD and disorders of pulmonary circulation associated with chronic respiratory failure, and are aiming to elucidate the pathogenesis and to find new therapies for these diseases.

Contact Information

TEL: 076-218-8157 / FAX: 076-286-0980 / Email:


Professor and Chair

  • MIZUNO Shiro 講座主任

Senior Assistant Professor

  • OIKAWA Taku
  • TAKAHARA Yutaka

Assistant Professor

  • SHINOMIYA Shohei
  • KATO Ryo
  • NOJIRI Masafumi
  • NAKASE Keisuke
  • NISHIKI Kazuaki
  • SAKUMA Takashi

Clinical Fellow

  • YAMAMURA Koichi

Research Achievements

Research Activities

  • Masafumi Nojiri, Shiro Mizuno, Kazuaki Nishiki, Ryo Kato, Ken Nakagawa, Taku Oikawa, Masaharu Iguchi, Kazuhiro Osanai, Takeshi Ishizaki, Hirohisa Toga. ADRB2 gene polymorphism and emphysema heterogeneity can modulate bronchodilator response in patients with emphysema. Pulmonary Pharmacology & Therapeutics, 48:80-87, 2018.
  • Mizuno S, Ishizaki T, Kadowaki M, Akai M, Shiozaki K, Iguchi M, Oikawa T, Nakagawa K, Osanai K, Toga H, Gomez-Arroyo J, Kraskauskas D, Cool CD, Bogaard HJ, Voelkel NF. p53 signaling pathway polymorphisms associated with emphysematous changes in COPD patients. Chest, 152:58-69, 2017.
  • Kato R, Mizuno S, Kadowaki M, Shiozaki K, Akai M, Nakagawa K, Oikawa T, Iguchi M, Osanai K, Ishizaki T, Voelkel NF, Toga H. Sirt1 expression is associated with CD31 expression in blood cells from patients with chronic obstructive pulmonary disease.・Respir Res. 17:139, 2016.
  • Mizuno S, Ishizaki T, Toga H. Role of p53 in lung tissue remodeling. World Journal of Respirology, 28; 5(1): 40-46, 2015.
  • Mizuno S, Ishizaki T, Toga H, Sakai, A, Isakova J, Taalaibekova E, Baiserkeev Z, Kojonazarov B, Aldashev A. Endogenous Asymmetric Dimethylarginine Pathway in High Altitude Adapted Yaks. Biomed Res Int, 196904, 2015.

External Research Funding

  • Grant-in-Aid for Scientific Research (B) 2016-2018 
    Shiro Mizuno Total amount 17,550,000 yen(Direct amount 13,500,000 yen)
  • Grant-in-Aid for Scientific Research (C) 2016-2018
    Shiro Mizuno Total amount 4,810,000 yen(Direct amount 3,700,000 yen)
  • Grant-in-Aid for Young Scientists (B) 2016-2017
    Masatoshi Saito Total amount 2,600,000 yen(Direct amount 2,000,000 yen)
  • The Hokkoku Cancer Foundation 2013
  • Grant-in-Aid for Scientific Research (C) 2012-2014
    Shiro Mizuno Total amount 5,330,000 yen(Direct amount 4,100,000 yen)